Organizational role for testosterone and estrogen on adult hypothalamic-pituitary-adrenal axis activity in the male rat.

@article{Seale2005OrganizationalRF,
  title={Organizational role for testosterone and estrogen on adult hypothalamic-pituitary-adrenal axis activity in the male rat.},
  author={Jenni Seale and Susan A. Wood and H C Atkinson and Stafford L. Lightman and Michael S. Harbuz},
  journal={Endocrinology},
  year={2005},
  volume={146 4},
  pages={1973-82}
}
Organizational effects of testosterone during a critical period of neonatal life have major irreversible effects on adult sexual behavior. We have investigated whether perinatal androgen changes also affect another major sexually differentiated system, the hypothalamo-pituitary-adrenal axis. This was assessed in male rats who had been exposed to perinatal flutamide or 1,4,6-androstatriene-3,17-dione (ATD). Once the animals reached adulthood, an automated sampling system was used to collect… CONTINUE READING

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