Organization of the origins of replication of the chromosomes of Mycobacterium smegmatis, Mycobacterium leprae and Mycobacterium tuberculosis and isolation of a functional origin from M. smegmatis.

@article{Salazar1996OrganizationOT,
  title={Organization of the origins of replication of the chromosomes of Mycobacterium smegmatis, Mycobacterium leprae and Mycobacterium tuberculosis and isolation of a functional origin from M. smegmatis.},
  author={Leiria Salazar and Hafida Fsihi and Edda De Rossi and Giovanna Riccardi and Camilo R{\'i}os and Stewart T Cole and Howard Eugene Takiff},
  journal={Molecular microbiology},
  year={1996},
  volume={20 2},
  pages={283-93}
}
The genus Mycobacterium is composed of species with widely differing growth rates ranging from approximately three hours in Mycobacterium smegmatis to two weeks in Mycobacterium leprae. As DNA replication is coupled to cell duplication, it may be regulated by common mechanisms. The chromosomal regions surrounding the origins of DNA replication from M. smegmatis, M. tuberculosis, and M. leprae have been sequenced, and show very few differences. The gene order, rnpA-rpmH-dnaA-dnaN-recF-orf-gyrB… CONTINUE READING