Organization of the myotendinous junction is dependent on the presence of alpha7beta1 integrin.

@article{Miosge1999OrganizationOT,
  title={Organization of the myotendinous junction is dependent on the presence of alpha7beta1 integrin.},
  author={Nicolai Miosge and C Klenczar and Rainer Herken and Michael Willem and Ulrike Mayer},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1999},
  volume={79 12},
  pages={
          1591-9
        }
}
The laminin receptor alpha7beta1 is enriched at the myotendinous junctions, and mice with a targeted inactivation of the alpha7 gene develop a form of muscular dystrophy that primarily affects this structure. By ultrastructural analysis of alpha7-deficient mice, in comparison with wild-type and mdx mice, we attempted to elucidate the role of alpha7 integrin for the integrity and function of the myotendinous junctions. Ultrastructurally, myotendinous junctions of alpha7-deficient myofibers lose… CONTINUE READING

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