Organization of the human orphan nuclear receptor Nurr1 gene.

@article{Torii1999OrganizationOT,
  title={Organization of the human orphan nuclear receptor Nurr1 gene.},
  author={Tsuyoshi Torii and T Kawarai and Shogo Nakamura and Hideaki Ohta-ku Kawakami},
  journal={Gene},
  year={1999},
  volume={230 2},
  pages={
          225-32
        }
}
Recent reports have revealed that Nurr1 (also known as NOT/TINUR/RNR-1/HZF-3), a member of the steroid/thyroid hormone nuclear receptor superfamily, is predominantly expressed in the midbrain; substantia nigra (SN) and ventral tegmental area (VTA). Nurr1 null mice are born lethal, lacking the midbrain dopamine (DA) neurons, suggesting that Nurr1 is essential for the development and differentiation of midbrain DA neurons. Human Nurr1 gene has been mapped on chromosome 2q22-23, which is reported… CONTINUE READING
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