Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1

@article{Carroll1988OrganizationOT,
  title={Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1},
  author={Michael C Carroll and Elisabeth M. Alicot and Philip Katzman and Lloyd B. Klickstein and Jennifer A. Smith and Douglas T Fearon},
  journal={The Journal of Experimental Medicine},
  year={1988},
  volume={167},
  pages={1271 - 1280}
}
The organization and physical linkage of four members of a major complement locus, the RCA locus, have been determined using the technique of pulsed field gradient gel electrophoresis in conjunction with Southern blotting. The genes encoding CR1, CR2, DAF, and C4bp were aligned in that order within a region of 750 kb. In addition, the 5' to 3' orientation of the CR1 gene (5' proximal to CR2) was determined using 5'- and 3'-specific DNA probes. The proximity of these genes may be related to… CONTINUE READING
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A complement receptor locus : genes encoding C 3 b / C 4 b receptor and C 3 d / Epstein - Barr virus receptor map to Ig 32

  • R. D. Bentley
  • J . Immunol .
  • 1987

Human C3b/C4b receptor

  • Fearon
  • Demonstration of long homolo-
  • 1987

Restriction analysis of chromosomal DNA in a size range up to two million base pairs by pulse field gradient electrophoresis

  • K. E. Davis
  • Analysis of Human Genetic Disease .
  • 1986

Structural analysis of human complement protein H : homology with C 4 b binding protein , beta 2 - glycoprotein 1 , and the Ba fragment of Bf

  • D. T. Fearon
  • J . Immunol .
  • 1986

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