Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

@article{Shimizu1982OrganizationOT,
  title={Organization of the constant-region gene family of the mouse immunoglobulin heavy chain},
  author={A. Shimizu and N. Takahashi and Y. Yaoita and T. Honjo},
  journal={Cell},
  year={1982},
  volume={28},
  pages={499-506}
}
  • A. Shimizu, N. Takahashi, +1 author T. Honjo
  • Published 1982
  • Biology, Medicine
  • Cell
  • We cloned overlapping DNA segments that encompass the region from the immunoglobulin JH segments to the C gamma 3 gene of BALB/c mouse. We have now cloned the entire region (about 200 kilobases) of the constant-region gene family of the immunoglobulin heavy chain, the organization of which is 5'-JH-6.5 kb-C mu-4.5 kb-C delta-55 kb-C gamma 3-34 kb-C gamma 1-21 kb-C gamma 2b-15 kb-C gamma 2a-14 kb-C epsilon-12 kb-C alpha-3'. Using these cloned DNAs, we have characterized several structural… CONTINUE READING
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