Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

@article{Shimizu1982OrganizationOT,
  title={Organization of the constant-region gene family of the mouse immunoglobulin heavy chain},
  author={Akira Shimizu and Naoki Takahashi and Yoshio Yaoita and Tasuku Honjo},
  journal={Cell},
  year={1982},
  volume={28},
  pages={499-506}
}
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The results implicate that the nucleotide sequence of the intervening sequence is under selective pressure, possibly to maintain a secondary structure of the nuclear RNA to be spliced, and implicates that the class of the immunoglobulinheavy chain genes diverged after the heavy chain genes established the multi-domain structure.
5′ Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains
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A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4A lambda phage vector system, was shown to contain the mu heavy chain constant region (CHmu) gene for the mouse…
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TLDR
The lack of homology between this C alpha sequence and sequences reported for the C gamma 1 and C gamma 2b switch sites suggests that heavy chain switching is mediated by class-specific recognition sequences and, presumably, class- specific regulatory mechanisms.
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TLDR
Comparison of nucleotide sequences of CH genes indicates that immunoglobulin genes have scrambled by intervening sequence-mediated domain transfer during their evolution.
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