Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

@article{Shimizu1982OrganizationOT,
  title={Organization of the constant-region gene family of the mouse immunoglobulin heavy chain},
  author={Akira Shimizu and Naoki Takahashi and Yoshio Yaoita and Tasuku Honjo},
  journal={Cell},
  year={1982},
  volume={28},
  pages={499-506}
}
Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon
TLDR
Results provide evidence that in murine non-B cells the IgCH, J, and D loci are part of a single replicon, similar to the rate measured for mammalian replicons by autoradiography and electron microscopy.
Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon.
TLDR
Results provide evidence that in murine non-B cells the IgCH, J, and D loci are part of a single replicon, similar to the rate measured for mammalian replicons by autoradiography and electron microscopy.
Class switch recombination of the chicken IgH chain genes: implications for the primordial switch region repeats.
TLDR
A primordial palindromic sequence from which the prevalent switch repeat motifs of mammals, chickens and amphibians may have diverged is presented.
Nucleotide sequences of all the γ gene loci of murine immunoglobulin heavy chains
TLDR
The nucleotide sequence of the entire region that encodes the γ chains of mouse immunoglobulin was determined and Duplication of a primordial γ2 gene seems likely to have occurred by homologous recombination that involved the 3′CR sequences.
Rat immunoglobulin E heavy chain locus.
Unusual sequences in the murine immunoglobulin μ–δ heavy-chain region
TLDR
The complete sequence as well as the sequence of the introns of the Cδ gene are presented and it is determined that the 3′ deletion end point of an IgD-producing myeloma is determined and no sequences reminiscent of switch sites nearby are found.
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The results implicate that the nucleotide sequence of the intervening sequence is under selective pressure, possibly to maintain a secondary structure of the nuclear RNA to be spliced, and implicates that the class of the immunoglobulinheavy chain genes diverged after the heavy chain genes established the multi-domain structure.
Exon shuffling generates an immunoglobulin heavy chain gene.
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A model suggesting how the phenomenon of switch seen in lymphocytes may occur is presented, suggesting that at least two recombination events occurred to create the gamma 2b gene in MOPC 141.
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A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4A lambda phage vector system, was shown to contain the mu heavy chain constant region (CHmu) gene for the mouse
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The lack of homology between this C alpha sequence and sequences reported for the C gamma 1 and C gamma 2b switch sites suggests that heavy chain switching is mediated by class-specific recognition sequences and, presumably, class- specific regulatory mechanisms.
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TLDR
Comparison of nucleotide sequences of CH genes indicates that immunoglobulin genes have scrambled by intervening sequence-mediated domain transfer during their evolution.
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