Organization of the Arp2/3 complex in hippocampal spines.

  title={Organization of the Arp2/3 complex in hippocampal spines.},
  author={Bence R{\'a}cz and Richard J. Weinberg},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={28 22},
Changes in the morphology of a dendritic spine require remodeling of its actin-based cytoskeleton. Biochemical mechanisms underlying actin remodeling have been studied extensively, but little is known about the physical organization of the actin-binding proteins that mediate remodeling in spines. Long-term potentiation-inducing stimuli trigger expansion of the spine head, suggesting local extension and branching of actin filaments. Because filament branching requires the Arp2/3 complex, we used… CONTINUE READING
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