Organization of stem cells and their progeny in human epidermis.


Renewal of epidermis is achieved by an ordered replication of stem cells and transit amplifying cells followed by terminal differentiation. In mouse epidermis, renewal is organized around highly ordered structures termed epidermal proliferative units (EPU), each generated by a single stem cell. It has been difficult to apply these concepts to the human… (More)
DOI: 10.1111/j.0022-202X.2004.23599.x


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