Organization of metabolic pathways in vastus lateralis of patients with chronic obstructive pulmonary disease.

@article{Green2008OrganizationOM,
  title={Organization of metabolic pathways in vastus lateralis of patients with chronic obstructive pulmonary disease.},
  author={Henry James Green and E. B. Bombardier and Margaret Elizabeth Burnett and Sobia Iqbal and Christine Linda D'Arsigny and Dennis Einan O'Donnell and Jing Ouyang and Katherine Alexandra Webb},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={295 3},
  pages={R935-41}
}
The objective of this study was to determine whether patients with chronic obstructive lung disease (COPD) display differences in organization of the metabolic pathways and segments involved in energy supply compared with healthy control subjects. Metabolic pathway potential, based on the measurement of the maximal activity (V(max)) of representative enzymes, was assessed in tissue extracted from the vastus lateralis in seven patients with COPD (age 67 +/- 4 yr; FEV(1)/FVC = 44 +/- 3%, where… CONTINUE READING