Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling

@article{Murtagh2004OrganizationOM,
  title={Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling},
  author={Janice Murtagh and Emmett McArdle and Emer Gilligan and Laura M Thornton and Fiona Furlong and Finian M Martin},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={166},
  pages={133 - 143}
}
Mammary epithelial cells cultured on a concentrated laminin-rich extracellular matrix formed 3D acinar structures that matured to polarized monolayers surrounding a lumen. In the absence of glucocorticoids mature acinus formation failed and the expression of an acinus-associated, activator protein 1 (AP1) and nuclear factor kappaB transcription factor DNA-binding profile was lost. Treatment with the JNK inhibitor, SP600125, caused similar effects, whereas normal organization of the mammary… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Differences in growth and transcriptomic profile of bovine mammary epithelial monolayer and three-dimensional cell cultures.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society • 2009
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…