Organization of iron-sulfur clusters in respiratory complex I.

  title={Organization of iron-sulfur clusters in respiratory complex I.},
  author={Philip Hinchliffe and Leonid A. Sazanov},
  volume={309 5735},
Complex I of respiratory chains plays a central role in bioenergetics and is implicated in many human neurodegenerative diseases. An understanding of its mechanism requires a knowledge of the organization of redox centers. The arrangement of iron-sulfur clusters in the hydrophilic domain of complex I from Thermus thermophilus has been determined with the use of x-ray crystallography. One binuclear and six tetranuclear clusters are arranged, maximally 14 angstroms apart, in an 84-angstrom-long… CONTINUE READING

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