Organization of endogenous opiate and nonopiate pain control systems.

@article{Watkins1982OrganizationOE,
  title={Organization of endogenous opiate and nonopiate pain control systems.},
  author={Linda R. Watkins and Dr. Jaques Mayer},
  journal={Science},
  year={1982},
  volume={216 4551},
  pages={1185-92}
}
Research during the past decade has revealed the existence of neural systems that modulate pain transmission. Much of this work has focused on the role of endogenous opiate systems, but recent research indicates the involvement of nonopiate mechanisms as well. In this article, we present data demonstrating that opiate and nonopiate analgesia systems can be selectively activated by different environmental manipulations and describe the neural circuitry involved. Both neural and hormonal pathways… CONTINUE READING

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