Organization of dopamine and serotonin system: Anatomical and functional mapping of monosynaptic inputs using rabies virus

@article{Ogawa2018OrganizationOD,
  title={Organization of dopamine and serotonin system: Anatomical and functional mapping of monosynaptic inputs using rabies virus},
  author={Sachie K. Ogawa and Mitsuko Watabe-Uchida},
  journal={Pharmacology Biochemistry and Behavior},
  year={2018},
  volume={174},
  pages={9-22}
}
ABSTRACT Dopamine and serotonin play critical roles in flexible behaviors and are related to various psychiatric and motor disorders. [...] Key Method We then describe quantitative comparisons across the data regarding monosynaptic inputs to dopamine neurons versus serotonin neurons. There is surprising similarity between the input to dopamine neurons in the ventral tegmental area (VTA) and the input to serotonin neurons in the dorsal raphe (DR), suggesting functional interactions between these systems. We next…Expand
Conventional and Novel Pharmacological Approaches to Treat Dopamine-Related Disorders: Focus on Parkinson’s Disease and Schizophrenia
TLDR
The aim of this work is to review some novel and conventional approaches that either have been used or are currently employed to treat brain diseases such as Parkinson´s disease and schizophrenia, with particular attention to approaches derived from the knowledge recently acquired in the realm of receptor-receptor interactions taking place through multiple dopamine heteroreceptor complexes in the plasma membrane.
Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System
TLDR
This review discusses how dopaminergic, serotonin, and endocannabinoid systems interact at the cellular and circuit levels, and the potential relevance for motivated behavior.
Selective vulnerability of dorsal raphe‐medial prefrontal cortex projection neurons to corticosterone‐induced hypofunction
TLDR
The results suggest that the serotonergic regulation of cognitive and emotional networks in the mPFC may be more sensitive to the effects of glucocorticoid excess than visual sensory circuits in the LGN and that reduced 5‐HT transmission in the pFC may underlie the association between glucoc Corticosterone excess and depression.
Interactions Between the Serotonergic and Other Neurotransmitter Systems in the Basal Ganglia: Role in Parkinson’s Disease and Adverse Effects of L-DOPA
TLDR
The role of the serotonergic system in LID is discussed and if therapeutic approaches specifically targeting this system may constitute an effective strategy in PD is discussed.
A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction
TLDR
A hypothesis of a critical period, during which the inputs of the mPFC compete for target innervation, establishing specific prefrontal network configurations in the adult brain is proposed.
Habenular connections with the dopaminergic and serotonergic system and their role in stress‐related psychiatric disorders
TLDR
Research is summarized about the topography and transmitter phenotype of the reciprocal connections between the LHb and ventral tegmental area‐nigra complex, as well as those between the RHb and DR/MnR and the role of specific LHb‐VTA and LHb/MHb‐raphe circuits in anxiety and depression.
Integrated anatomical and physiological mapping of striatal afferent projections
TLDR
A basic uniform connectivity map for striatal afferent inputs upon which presynaptic–postsynaptic interactions impose substantial diversity of physiological connectivity is suggested.
Whole-Brain Mapping of Direct Inputs to Dopamine D1 and D2 Receptor-Expressing Medium Spiny Neurons in the Posterior Dorsomedial Striatum
TLDR
It is found that D1-MSNs preferentially received inputs from the secondary motor, secondary visual, and cingulate cortices, whereas D2- MSNs received input from the primary motor and primary sensory cortice, and the thalamus.
Differences in Functional Connectivity Networks Related to the Midbrain Dopaminergic System-Related Area in Various Psychiatric Disorders.
TLDR
The results suggest that altered brain functional connectivity related to VTA networks could be associated with the distinctive pathophysiologies of psychiatric disorders, especially affective disorders.
Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
TLDR
It is found that inhibition of mTORC1 strongly and broadly impacts dopamine neuron structure and function causing somatodendritic and axonal hypotrophy, increased intrinsic excitability, decreased dopamine production, and impaired dopamine release.
...
1
2
...

References

SHOWING 1-10 OF 99 REFERENCES
Organization of monosynaptic inputs to the serotonin and dopamine neuromodulatory systems.
TLDR
A modified rabies virus is used to identify monosynaptic inputs to serotonin neurons in the dorsal and median raphe (DR and MR) and suggests three major input streams: a medial stream regulates MR serotonin neurons, an intermediate stream regulates DR serotonin and VTA dopamine neurons, and a lateral stream regulates SNc dopamine neurons.
Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons
TLDR
This work comprehensively identified each area's monosynaptic inputs using the rabies virus to show that dopamine neurons in both areas integrate inputs from a more diverse collection of areas than previously thought, including autonomic, motor, and somatosensory areas.
Presynaptic Partners of Dorsal Raphe Serotonergic and GABAergic Neurons
TLDR
Using viral tracing combined with electrophysiology, it is found that GABA and serotonin neurons in the DR receive excitatory, inhibitory, and peptidergic inputs from the same specific brain regions.
A Whole-Brain Atlas of Inputs to Serotonergic Neurons of the Dorsal and Median Raphe Nuclei
TLDR
A comprehensive whole-brain atlas defining the monosynaptic inputs onto forebrain-projecting serotonergic neurons of dorsal versus median raphe based on a genetically restricted transsynaptic retrograde tracing strategy is generated.
Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping
TLDR
The utility of viral-genetic tracing strategies to elucidate the complex neural substrates that underlie motivated behaviors is highlighted, including a previously unappreciated top-down reinforcing circuit from anterior cortex to lateral nucleus accumbens via VTA-DA neurons.
Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass
TLDR
The results lay a foundation for understanding the input/output structure of the midbrain dopamine circuit and demonstrate that dopamine neurons projecting to the posterior striatum constitute a unique class of dopamine neurons regulated by different inputs.
Ascending serotonin neuron diversity under two umbrellas
  • K. Commons
  • Psychology, Medicine
    Brain Structure and Function
  • 2015
TLDR
New insight into the afferent and efferent connectivity of the dorsal and median raphe nuclei (DR and MR) is reviewed in correlation with their developmental origin, suggesting that the caudal third of the DR, the area originally designated B6, may be misidentified as part of theDR as it shares many features of connectivity with the MR.
Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications.
TLDR
Electrophysiological and biochemical data are presented showing that endogenous 5-HT and pharmacological5-HT ligands modify the mesencephalic DA systems' activity and the functional interaction between the two monoamines will be discussed.
Striatonigrostriatal Pathways in Primates Form an Ascending Spiral from the Shell to the Dorsolateral Striatum
TLDR
Examination of results from multiple tracing experiments simultaneously demonstrates an interface between different striatal regions via the midbrain dopamine cells that forms an ascending spiral between regions that provides an anatomical basis for the limbic/cognitive/motor interface via the ventral midbrain.
Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons
TLDR
A monosynaptic rabies virus system is used to generate brain-wide maps of neurons that form synapses with direct- or indirect-pathway striatal projection neurons, and it is discovered that sensory cortical and limbic structures preferentially innervated the direct pathway, whereas motor cortexPreferentially targeted the indirect pathway.
...
1
2
3
4
5
...