Organization of chromosomes in spermatozoa: an additional layer of epigenetic information?

@article{Zalensky2007OrganizationOC,
  title={Organization of chromosomes in spermatozoa: an additional layer of epigenetic information?},
  author={Andrei O. Zalensky and Irina A. Zalenskaya},
  journal={Biochemical Society transactions},
  year={2007},
  volume={35 Pt 3},
  pages={609-11}
}
Elaborate non-random organization of human sperm chromosomes at different structural levels, starting from the DNA packing by protamines up to the higher-order chromosome configuration and nuclear positioning of chromosome territories, has been discovered. Here, we put forward a hypothesis that the unique genome architecture in sperm provides a mechanism for orchestrated unpacking and ordered activation of the male genome during fertilization, thus offering an additional level of epigenetic… CONTINUE READING