Organization of action sequences and the role of the pre-SMA.

@article{Kennerley2004OrganizationOA,
  title={Organization of action sequences and the role of the pre-SMA.},
  author={Steven Wayne Kennerley and K{\^o} Sakai and Matthew F. S. Rushworth},
  journal={Journal of neurophysiology},
  year={2004},
  volume={91 2},
  pages={
          978-93
        }
}
To understand the contribution of the human presupplementary motor area (pre-SMA) in sequential motor behavior, we performed a series of finger key-press experiments. Experiment 1 revealed that each subject had a spontaneous tendency to organize or "chunk" a long sequence into shorter components. We hypothesized that the pre-SMA might have a special role in initiating each chunk but not at other points during the sequence. Experiment 2 therefore examined the effect of 0.5-s, 10-Hz repetitive… 
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References

SHOWING 1-10 OF 106 REFERENCES
Presupplementary Motor Area Activation during Sequence Learning Reflects Visuo-Motor Association
TLDR
Activation of the pre-SMA was related to the extent to which the task performance depended on conscious visuo-motor associations, and the decrease of pre- SMA activation in the sequential paradigms may reflect the process by which individual vis Luo-m motor associations were replaced by the formation of sequential procedural memory.
Evidence for Lasting Sequence Segmentation in the Discrete Sequence-Production Task
TLDR
It is suggested that practice induces the development of motor chunks, each representing a short segment, and with longer sequences a control scheme for concatenating the motor chunks.
Both supplementary and presupplementary motor areas are crucial for the temporal organization of multiple movements.
TLDR
Control experiments on two separate monkeys found that injections of the same amount of muscimol into either the SMA or pre-SMA did not cause problems with nonsequential reaching movement regardless of whether it was visually triggered or self-initiated.
Neuronal activity in the supplementary and presupplementary motor areas for temporal organization of multiple movements.
TLDR
How neurons in the SMA and pre-SMA are involved in sequencing multiple movements over time is suggested, with neuronal activity representing the rank order of three movements arranged chronologically being of particular interest.
Stimulation over the human supplementary motor area interferes with the organization of future elements in complex motor sequences.
TLDR
High-frequency repetitive transcranial magnetic stimulation (rTMS) was used to study the role of the mesial frontocentral cortex (including the supplementary motor area) in the organization of sequential finger movements of different complexity in humans, indicating a critical role in the organizations of forthcoming movements in complex motor sequences that are rehearsed from memory and fit into a precise timing plan.
Movement sequence-related activity reflecting numerical order of components in supplementary and presupplementary motor areas.
TLDR
It is concluded that neurons in SMA and pre-SMA may encode the numerical order of components, at least for sequences that are distinguished mainly by that aspect of component ordering.
rTMS to the supplementary motor area disrupts bimanual coordination.
TLDR
The results suggest that the rostral parts of the SMA play an important role in aspects of functional bimanual tasks, which involve tight temporal coordination between different motor actions of the two hands.
Subregions within the Supplementary Motor Area Activated at Different Stages of Movement Preparation and Execution
TLDR
High temporospatial resolution of functional magnetic resonance imaging (fMRI) was used to study the relationship between stages of a motor program and activation of these motor-related cortical areas and supported the notion that the classic SMA consists of the pre-SMA and SMA proper each with different functions.
Influence of transcranial magnetic stimulation on the execution of memorised sequences of saccades in man
TLDR
TMS can interfere specifically with the function of the SMA during a critical time interval close to the go-signal, as shown in animal experiments and in humans with isolated SMA lesions.
Effects of local inactivation of monkey medial frontal cortex in learning of sequential procedures.
TLDR
It is suggested that the medial frontal cortex, especially pre-SMA, is related to the acquisition, rather than the storage or execution, of the correct order of button presses.
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