Organization and structure of the Qa genes of the major histocompatibility complex of the C3H mouse: implications for Qa function and class I evolution.

@article{Watts1989OrganizationAS,
  title={Organization and structure of the Qa genes of the major histocompatibility complex of the C3H mouse: implications for Qa function and class I evolution.},
  author={Suzanne Watts and Ann Cranmer Davis and Brandon S. Gaut and Calvin Wheeler and Linzy Hill and Robert S. Goodenow},
  journal={The EMBO journal},
  year={1989},
  volume={8 6},
  pages={1749-59}
}
We have determined the structure and organization of the entire Qa family of class I genes from the major histocompatibility complex of the C3H mouse. Restriction maps of overlapping lambda and cosmid clones reveal that there are only five Qak genes: Q1k, Q2k, Q4k, Q10k and a Q5/9 hybrid, presumably generated by unequal homologous recombination. The resulting deletion of Q6-Q9 is consistent with the Qa-2null phenotype of this mouse strain. We have sequenced the Qak genes, and predict that each… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Identification of a novel repressive element that contributes to neuron-specific gene expression.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1997
View 4 Excerpts
Highly Influenced

A physical map of the Q region of B10.P

View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…