Organization and regulation of mitogen-activated protein kinase signaling pathways.

@article{Garrington1999OrganizationAR,
  title={Organization and regulation of mitogen-activated protein kinase signaling pathways.},
  author={Timothy P Garrington and Gary Leon Johnson},
  journal={Current opinion in cell biology},
  year={1999},
  volume={11 2},
  pages={211-8}
}
Mitogen-activated protein kinases (MAPKs) are components of a three kinase regulatory cascade. There are multiple members of each component family of kinases in the MAPK module. Specificity of regulation is achieved by organization of MAPK modules, in part, by use of scaffolding and anchoring proteins. Scaffold proteins bring together specific kinases for selective activation, sequestration and localization of signaling complexes. The recent elucidation of scaffolding mechanisms for MAPK… CONTINUE READING
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