Organization and promoter analysis of the zebrafish (Danio rerio) chemokine gene (CXC-64) promoter

  title={Organization and promoter analysis of the zebrafish (Danio rerio) chemokine gene (CXC-64) promoter},
  author={Li-Chen Chen and Jen-Leih Wu and C Y Shiau and Jyh-Yih Chen},
  journal={Fish Physiology and Biochemistry},
Zebrafish CXC-64, a chemokine representing a superfamily of chemotactic cytokines present in fish, is involved in recruitment, activation, and response to inflammatory stimulation. We cloned and sequenced the genomic DNA of the zebrafish CXC-64 chemokine; it was most similar to CXCL11 from humans and CXCL10 from a catfish. The zebrafish CXC-64 gene is approximately 4.0 kb long and has a four-exon, three-intron structure common to the human CXCL11 gene. However, the promoter region includes a… CONTINUE READING


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