Organization and function of the 3D genome

  title={Organization and function of the 3D genome},
  author={Boyan B. Bonev and Giacomo Cavalli},
  journal={Nature Reviews Genetics},
Understanding how chromatin is organized within the nucleus and how this 3D architecture influences gene regulation, cell fate decisions and evolution are major questions in cell biology. Despite spectacular progress in this field, we still know remarkably little about the mechanisms underlying chromatin structure and how it can be established, reset and maintained. In this Review, we discuss the insights into chromatin architecture that have been gained through recent technological… 
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