Organization and expression of the Cyr61 gene in normal human fibroblasts.

@article{Leng2002OrganizationAE,
  title={Organization and expression of the Cyr61 gene in normal human fibroblasts.},
  author={Esther C Leng and Tom Malcolm and Georgia Tai and Mario Clemente Estable and Ivan Sadowski},
  journal={Journal of biomedical science},
  year={2002},
  volume={9 1},
  pages={59-67}
}
We have examined the human Cyr61 gene and its expression in normal fibroblasts. The core promoter, second intron, and 3' untranslated region (UTR) are highly conserved between the human and mouse genes. Cyr61 expression was induced slightly slower but more transiently in human fibroblasts compared to Rat-2 fibroblasts. These differences may relate to the absence of a serum response element in the human Cyr61 promoter, and the presence of additional AU-rich elements within the 3' UTR… CONTINUE READING

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