Organization and evolution of multifunctional Ca(2+)/CaM-dependent protein kinase genes.

@article{Tombes2003OrganizationAE,
  title={Organization and evolution of multifunctional Ca(2+)/CaM-dependent protein kinase genes.},
  author={Robert M. Tombes and Milton O Faison and J McClintock Turbeville},
  journal={Gene},
  year={2003},
  volume={322},
  pages={17-31}
}
The "multi-functional" Ca(2+) and calmodulin-dependent protein kinase, type II (CaMK-II) is an evolutionarily conserved protein. It has been found as a single gene in the horseshoe crab, marine sponge, sea urchin, nematode, and fruit fly, whereas most vertebrates possess four genes (alpha, beta, gamma, and delta). Species from fruit flies to humans encode alternative splice variants which are differentially targeted to phosphorylate diverse downstream targets of Ca(2+) signaling. By comparing… CONTINUE READING
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