Organization and adhesive properties of the hyaluronan pericellular coat of chondrocytes and epithelial cells.

@article{Cohen2003OrganizationAA,
  title={Organization and adhesive properties of the hyaluronan pericellular coat of chondrocytes and epithelial cells.},
  author={Miriam Cohen and C. G. A. Harrison and Benjamin Geiger and Lia Addadi},
  journal={Biophysical journal},
  year={2003},
  volume={85 3},
  pages={
          1996-2005
        }
}
Hyaluronan is a megadalton glycosaminoglycan composed of repeating units of D-N-acetylglucosamine-beta-D-Glucuronic acid. It is known to form a highly hydrated pericellular coat around chondrocytes, fibrosarcoma, and smooth muscle cells. Using environmental scanning electron microscopy we detected fully hydrated hyaluronan pericellular coats around rat chondrocytes (RCJ-P) and epithelial cells (A6). Hyaluronan mediates early adhesion of both chondrocytes and A6 cells to glass surfaces. We show… CONTINUE READING
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