Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin.

@article{TombranTink1996OrganizationEC,
  title={Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin.},
  author={Joyce Tombran-Tink and Krzysztof Mazuruk and Ignacio R. Rodriguez and D Chung and Torsten Linker and Ernest J. Englander and Gerald J. Chader},
  journal={Molecular vision},
  year={1996},
  volume={2},
  pages={11}
}
PEDF is a neurotrophic serpin that promotes a neuronal phenotype and augments neuronal cell survival. The isolation, sequence and structural analysis of the human PEDF gene and its promoter along with its evolutionary conservation and expression in human tissues are now described. The gene spans approximately 16 kb and is divided among 8 exons and 7 introns, the junctions of which conform to the AG/GT consensus rule. PEDF appears to fall into the ovalbumin/PAI-2 subgrouping of serpins and is… CONTINUE READING

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