Organization, development and function of complex brain networks

@article{Sporns2004OrganizationDA,
  title={Organization, development and function of complex brain networks},
  author={Olaf Sporns and Dante R. Chialvo and Marcus Kaiser and Claus C. Hilgetag},
  journal={Trends in Cognitive Sciences},
  year={2004},
  volume={8},
  pages={418-425}
}
Recent research has revealed general principles in the structural and functional organization of complex networks which are shared by various natural, social and technological systems. This review examines these principles as applied to the organization, development and function of complex brain networks. Specifically, we examine the structural properties of large-scale anatomical and functional brain networks and discuss how they might arise in the course of network growth and rewiring… Expand

Figures and Topics from this paper

Paper Mentions

Interventional Clinical Trial
1. Study rationale - Nielsen et al reported that after 6 weeks of amisulpride treatment, patients with schizophrenia showed an increase in the anticipation-related functional… Expand
ConditionsSchizophrenia, Schizophreniform Disorder
InterventionDrug
Blog Post
Structural and functional clusters of complex brain networks
Recent research using the complex network approach has revealed a rich and complicated network topology in the cortical connectivity of mammalian brains. It is of importance to understand theExpand
Structure and function of complex brain networks
  • O. Sporns
  • Psychology, Medicine
  • Dialogues in clinical neuroscience
  • 2013
TLDR
Network methods are increasingly applied in a clinical context, and their promise for elucidating neural substrates of brain and mental disorders is discussed. Expand
Modular Brain Networks.
TLDR
A number of methods for detecting modules in both structural and functional brain networks are surveyed and their potential functional roles in brain evolution, wiring minimization, and the emergence of functional specialization and complex dynamics are considered. Expand
Organization and Function of Complex Cortical Networks
This review gives a general overview of the organization of complex brain networks at the systems level, in particular in the cerebral cortex of the cat brain. We identify fundamental parameters ofExpand
Large-scale brain networks in cognition: emerging methods and principles
TLDR
It is argued that the emerging science of large-scale brain networks provides a coherent framework for understanding of cognition that allows a principled exploration of how cognitive functions emerge from, and are constrained by, core structural and functional networks of the brain. Expand
Multiscale Network Organization in the Human Brain
The human brain is a complex system whose function is made possible through coordinated patterns of activity over multiple spatial and temporal scales. Network theory can be used to create aExpand
Complex brain networks: graph theoretical analysis of structural and functional systems
TLDR
This article reviews studies investigating complex brain networks in diverse experimental modalities and provides an accessible introduction to the basic principles of graph theory and highlights the technical challenges and key questions to be addressed by future developments in this rapidly moving field. Expand
Network assemblies in the functional brain.
TLDR
Functional connectivity MRI and corresponding analytical tools continue to reveal novel properties of the functional organization of the brain, which will in turn be key for understanding pathologies in neurology. Expand
The human connectome: a complex network
  • O. Sporns
  • Computer Science, Medicine
  • Annals of the New York Academy of Sciences
  • 2011
TLDR
Current empirical efforts toward generating a network map of the human brain, the human connectome, are reviewed, and how the connectome can provide new insights into the organization of the brain's structural connections and their role in shaping functional dynamics are explored. Expand
Hierarchical organization unveiled by functional connectivity in complex brain networks.
TLDR
This work study synchronization dynamics in the cortical brain network of the cat finds that in the biologically plausible regime the dynamics exhibits a hierarchical modular organization, in particular, revealing functional clusters coinciding with the anatomical communities at different scales. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 110 REFERENCES
Modelling the development of cortical systems networks
TLDR
A computational model of spatial network growth was developed to investigate the conditions leading to similar network density and clustering as found in the cortical connectivity of cat and macaque monkey, which suggests that cortical networks may trade perfect minimal wiring length for shorter average shortest paths among cortical areas. Expand
Classes of network connectivity and dynamics
TLDR
Different classes of network are identified, including networks that are characterized by high complexity, which have distinct structural characteristics such as clustered connectivity and short wiring length similar to those of large-scale networks of the cerebral cortex. Expand
Motifs in Brain Networks
TLDR
This analysis suggests the hypothesis that brain networks maximize both the number and the diversity of functional motifs, while the repertoire of structural motifs remains small, and obtains network topologies that resemble real brain networks across a broad spectrum of structural measures, including small-world attributes. Expand
Large-scale cortical networks and cognition
  • S. Bressler
  • Medicine, Psychology
  • Brain Research Reviews
  • 1995
TLDR
A substantial body of evidence is examined supporting the view that complex integrative functions are carried out by large-scale networks of cortical areas, and the functional topology of a large- scale cortical network is dynamically reorganized during visuomotor behavior. Expand
Complex Neural Dynamics
TLDR
This chapter provides a brief overview of current concepts and models of how structured brain connectivity gives rise to complex neural dynamics. Expand
Computational analysis of functional connectivity between areas of primate cerebral cortex.
TLDR
A relational database is built up by systematically collating published data on the spread of activity after strychnine-induced disinhibition in the macaque cerebral cortex in vivo to demonstrate that the cortical network of functional interactions is not homogeneous, but shows a clear segregation into functional assemblies of mutually interacting areas. Expand
Analysis of the connectional organization of neural systems associated with the hippocampus in rats.
  • Gully A. Burns, M. Young
  • Computer Science, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2000
TLDR
The consistency between the analyses of connectivity and the distribution of physiological properties across the system suggests that functional relationships are constrained by the organization of the connectivity of the system, and so that structure and function are linked at the systems level. Expand
Theoretical neuroanatomy: relating anatomical and functional connectivity in graphs and cortical connection matrices.
TLDR
It is hypothesized that adaptation to rich sensory environments and motor demands requires complex dynamics and that these dynamics are supported by neuroanatomical motifs that are characteristic of the cerebral cortex. Expand
Anatomical connectivity defines the organization of clusters of cortical areas in the macaque monkey and the cat.
TLDR
Computational analyses capable of showing whether clusters of strongly interconnected areas are aspects of the global organization of cortical systems in macaque and cat show that structure and function are closely linked at this gross, systems level. Expand
Network participation indices: characterizing component roles for information processing in neural networks
We propose a set of indices that characterize-on the basis of connectivity data-how a network node participates in a larger network and what roles it may take given the specific sub-network ofExpand
...
1
2
3
4
5
...