Organization, control and function of extrasynaptic NMDA receptors.

@article{Papouin2014OrganizationCA,
  title={Organization, control and function of extrasynaptic NMDA receptors.},
  author={Thomas Papouin and St{\'e}phane Henri Richard Oliet},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2014},
  volume={369 1654},
  pages={20130601}
}
N-methyl D-aspartate receptors (NMDARs) exist in different forms owing to multiple combinations of subunits that can assemble into a functional receptor. In addition, they are located not only at synapses but also at extrasynaptic sites. There has been intense speculation over the past decade about whether specific NMDAR subtypes and/or locations are responsible for inducing synaptic plasticity and excitotoxicity. Here, we review the latest findings on the organization, subunit composition and… CONTINUE READING

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impact on receptor properties, synaptic plasticity and disease

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