Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation.

@article{Sun2012OrganismalRO,
  title={Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation.},
  author={Jingru Sun and Yiyong Liu and Alejandro Aballay},
  journal={EMBO reports},
  year={2012},
  volume={13 9},
  pages={855-60}
}
The increased demand on protein folding in the endoplasmic reticulum (ER) during bacterial infection activates the unfolded protein response (UPR). OCTR-1--a G protein-coupled catecholamine receptor expressed in neurons--suppresses innate immunity by downregulating a non-canonical UPR pathway and the p38 MAPK pathway. Here, we show that OCTR-1 also regulates the canonical UPR pathway, which is controlled by XBP-1, at the organismal level. Importantly, XBP-1 is not under OCTR-1 control during… CONTINUE READING

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