Organisation of the murine 5‐HT3 receptor gene and assignment tohuman chromosome 11

@article{Uetz1994OrganisationOT,
  title={Organisation of the murine 5‐HT3 receptor gene and assignment tohuman chromosome 11},
  author={P. Uetz and F Abdelatty and Alfredo Villarroel and Gudrun A. Rappold and Birgit Weiss and Michael Koenen},
  journal={FEBS Letters},
  year={1994},
  volume={339}
}
Developmental Changes in the Differential Expression of Two Serotonin 5‐HT3 Receptor Splice Variants in the Rat
Abstract: PCR was used to isolate identical partial cDNA clones encoding a serotonin 5‐HT3 receptor subunit from rat nodose and superior cervical ganglia. The amino acid sequence predicted from these
Evidence for Expression of Heteromeric Serotonin 5‐HT3 Receptors in Rodents
TLDR
Functional data and expression patterns are consistent with the existence of heteromeric 5‐HT3 receptors in rodent neurons, and sequence analysis and functional studies suggest that the new rodent subunits are orthologues of the human 5-HT3B subunit.
The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts.
TLDR
Functional expression in HEK 293 cells of alpha3L and alpha3K subunits resulted in the formation of glycine-gated chloride channels that differed significantly in desensitization behavior, thus defining the cytoplasmic loop as an important determinant of channel inactivation kinetics.
Chromosomal localization of 15 ion channel genes
TLDR
The ESTs developed in this study can be used to isolate genomic clones, enabling the determination of each transcript's genomic structure and physical map location, and may aid in the identification of candidate genes for groups of related heritable disorders.
Functional characterization of two 5-HT3 receptor splice variants isolated from a mouse hippocampal cell line
TLDR
Two splice variants of the ligand-gated 5-hydroxytryptamine or serotonin 5-HT3 receptor that differ in a six-amino-acid deletion were cloned by polymerase chain reaction from the hippocampus x neuroblastoma cell line HN9.10e to reveal no significant differences in current responses to the agonists 5- HT and 1-phenylbiguanide.
Molecular cloning, functional expression, and pharmacological characterization of 5-hydroxytryptamine3 receptor cDNA and its splice variants from guinea pig.
TLDR
The data reveal that the cloned cDNAs code for guinea pig 5-HT3 receptors, which functionally assemble as homo-oligomers, and the kinetic behavior of the ion channel and its sensitivity to several agonists and antagonists were markedly different from those of theCloned 5- HT3 receptors from mouse and human under similar experimental conditions.
The Serotonin Receptor Subtype 5b Specifically Interacts with Serotonin Receptor Subtype 1A
TLDR
It is found that 5-ht5b receptors can specifically interact with 5-HT1A receptors and retain them in endosomal compartments, which possibly represents a mechanism by which 4 and fifth trans-membrane domain (TMD) regulates the activity of other 5- HT receptor.
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The murine chromosomal gene for the GABAA receptor delta subunit was isolated and characterized by high-resolution mapping and DNA sequencing and displays an intron pattern comparable, but not identical, to that seen in members of the nicotinic acetylcholine receptor family.
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    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1990
TLDR
Subpopulations of GABAA receptors with different cellular and regional locations show differential sensitivity to GABA, to modulators like steroids, to physiological regulation, to disease processes, and to pharmacological manipulation by drugs such as benzodiazepines.
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TLDR
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TLDR
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