Organisation of the chondrocyte cytoskeleton and its response to changing mechanical conditions in organ culture.

@article{Durrant1999OrganisationOT,
  title={Organisation of the chondrocyte cytoskeleton and its response to changing mechanical conditions in organ culture.},
  author={Lisa Durrant and Charles W. Archer and Mike Benjamin and Jim R. Ralphs},
  journal={Journal of anatomy},
  year={1999},
  volume={194 ( Pt 3)},
  pages={343-53}
}
Articular cartilage undergoes cycles of compressive loading during joint movement, leading to its cyclical deformation and recovery. This loading is essential for chondrocytes to perform their normal function of maintenance of the extracellular matrix. Various lines of evidence suggest the involvement of the cytoskeleton in load sensing and response. The purpose of the present study is to describe the 3-dimensional (3D) architecture of the cytoskeleton of chondrocytes within their extracellular… CONTINUE READING