Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.

@article{Hughes2009OrganisationOH,
  title={Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.},
  author={Helen Hughes and Annika Budnik and Katy Schmidt and K. J. Palmer and Judith Mantell and C. Noakes and Andrew D. Johnson and Deborah AL Carter and Paul Verkade and Peter Watson and David John Stephens},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 16},
  pages={2924-34}
}
The COPII complex mediates the selective incorporation of secretory cargo and relevant machinery into budding vesicles at specialised sites on the endoplasmic reticulum membrane called transitional ER (tER). Here, we show using confocal microscopy, immunogold labelling of ultrathin cryosections and electron tomography that in human cells at steady state, Sec16 localises to cup-like structures of tER that are spatially distinct from the localisation of other COPII coat components. We show that… CONTINUE READING

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