Organic solution versus aqueous dispersion of Eudragit RS in preparation of sustained release microparticles of theophylline using spray drying.

@article{Garekani2013OrganicSV,
  title={Organic solution versus aqueous dispersion of Eudragit RS in preparation of sustained release microparticles of theophylline using spray drying.},
  author={Hadi Afrasiabi Garekani and Z Fatemi Moghaddam and Fatemeh Sadeghi},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2013},
  volume={108},
  pages={374-9}
}
The aim of this study was to compare aqueous dispersion and organic solution of Eudragit RS in preparation of sustained release theophylline microparticles using spray drying technique. Spray dried samples (SD) with drug:polymer (D:P) ratios of 1:1, 1:2, 1:3 were prepared using aqueous dispersion (SDaq) or organic solutions of Eudragit RS in ethanol (SDor). Properties of spray dried samples including yield, particle morphology, size distribution and drug dissolution were examined. Differential… CONTINUE READING