Organic anions and potassium salts in nutrition and metabolism

@article{Demign2004OrganicAA,
  title={Organic anions and potassium salts in nutrition and metabolism},
  author={Christian Demign{\'e} and Houda Sabboh and Caroline Puel and Christian R{\'e}m{\'e}sy and V{\'e}ronique Coxam},
  journal={Nutrition Research Reviews},
  year={2004},
  volume={17},
  pages={249 - 258}
}
Abstract The present review examines the importance of dietary organic anions in preventive nutrition. Organic anions are chiefly supplied by plant foods, as partially neutralised K salts such as potassium citrate, potassium malate and, to a lesser extent, oxalate or tartrate salts. Animal products may also supply K anions, essentially as phosphate, but also as lactate as a result of fermentative or maturation processes, but these K salts have little alkalinising significance. Citrate and… 
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Effect of potassium salts in rats adapted to an acidogenic high-sulfur amino acid diet
TLDR
The present model of low-grade metabolic acidosis indicates that potassium malate may be as effective as KHCO3 to counteract urine acidification, to limit divalent cation excretion and to ensure high citrate concentration in urine.
Effects of plant food potassium salts (citrate, galacturonate or tartrate) on acid–base status and digestive fermentations in rats
TLDR
The present findings indicate that K salts of unabsorbed organic anions exert alkalinizing effects when metabolizable in the large intestine, even if K and finally available anions (likely SCFA) are not simultaneously bioavailable.
Excess Casein in the Diet Is Not the Unique Cause of Low-Grade Metabolic Acidosis: Role of a Deficit in Potassium Citrate in a Rat Model
TLDR
It is concluded that low-grade metabolic acidosis can occur with a moderate protein level in the diet, and K citrate greatly stimulated citraturia and 2-ketoglutarate excretion.
Protective effects of high dietary potassium: nutritional and metabolic aspects.
TLDR
Fruits and vegetables are receiving great attention in a strategy to increase the nutritional value of meals while reducing energy density and intake, and represent a strong rationale for the "5-10 servings per day" recommendations.
Organic potassium salts or fibers effects on mineral balance and digestive fermentations in rats adapted to an acidogenic diet
TLDR
Fibers and potassium (K) organic salts in plant foods are liable to affect Ca and Mg balance at digestive and renal levels, respectively, but seem to be not directly involved in the alkalinizing effects of plant foods.
Recent Advances in Nutritional Sciences Protective Effects of High Dietary Potassium : Nutritional and Metabolic Aspects 1 , 2
TLDR
The need to ensure a 2.5to 3.5-g daily K supply from fruits and vegetables represents a strong rationale for the “5–10 servings per day” recommendations, and receives great attention in a strategy to increase the nutritional value of meals while reducing energy density and intake.
Citrate, malate and alkali content in commonly consumed diet sodas: implications for nephrolithiasis treatment.
Malic acid supplementation increases urinary citrate excretion and urinary pH: implications for the potential treatment of calcium oxalate stone disease.
TLDR
It is speculated that consumption of malic acid induced systemic alkalinization leading to reduced renal tubular reabsorption and metabolism of citrate, and an increase in excretion of the latter.
Vegetable-Based Diets for Chronic Kidney Disease? It Is Time to Reconsider
Traditional dietary recommendations to renal patients limited the intake of fruits and vegetables because of their high potassium content. However, this paradigm is rapidly changing due to the…
Effects of dietary electrolyte balance and calcium supply on mineral and acid−base status of piglets fed a diversified diet
TLDR
A higher Ca supply must be considered in more diversified diets to counteract the risk of evolving towards low-grade metabolic acidosis which can negatively affect bone.
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