Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine.

@article{Chen2015OrganicAP,
  title={Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine.},
  author={Chen Chen and Zhi-tao Wu and Lei-lei Ma and Xuan Ni and Yun-fei Lin and Le Wang and Keping Chen and Cheng-gang Huang and Guoyu Pan},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2015},
  volume={45 12},
  pages={
          1138-46
        }
}
1. The purpose of this study was to investigate the mechanism of hepatic uptake of berberine. Berberine accumulation in hepatocytes was found to be highly dependent on active uptake, which could not be explained by liver organic cation transporter (OCT) alone. 2. Our studies indicated that berberine uptake was significantly suppressed by rifampicin, cyclosporine A and glycyrrhizic acid, which act as specific inhibitors of different Oatp isoforms (Oatp1a1, Oatp1a4 and Oatp1b2) in rat hepatocytes… CONTINUE READING

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