Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin

@article{Glaeser2014OrganicAT,
  title={Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin},
  author={Hartmut Glaeser and Krystyna Bujok and Ingrid Schmidt and Martin F. Fromm and Kathrin Mandery},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2014},
  volume={387},
  pages={883-891}
}
Flavonoids such as quercetin and kaempferol mediate several health protective effects, e.g., anticancer effects. They are inhibitors of organic anion transporting polypeptides (OATP) and organic cation transporters (e.g., OCT2). However, little is known whether such transporters contribute to the cellular uptake of flavonoids. Therefore, we investigated the cellular uptake of kaempferol and quercetin using HEK293 cell lines stably expressing different human OATPs or OCT1. Kaempferol was not a… 
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TLDR
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The data show that OCTs play an important physiological role for neurotransmitter balance in the body and, considering their high expression in excretory organs, together with MATEs are responsible for drug excretion.
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