Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.

@article{Bednarczyk2016OrganicAT,
  title={Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.},
  author={Dallas Bednarczyk and Carri Boiselle},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2016},
  volume={46 5},
  pages={457-66}
}
1. Organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 are polyspecific transporters that mediate the transport of organic acids into hepatocytes. Inactivating mutations of both OATP1B1 and OATP1B3 alleles lead to Rotor syndrome, a disease characterized by coproporphyrinuria, an elevated urinary excretion of coproporphyrins I and III. It was hypothesized that transport of coproporphyrins I and III was mediated by OATP1B1 and OATP1B3. 2. This hypothesis was tested using cells transfected… CONTINUE READING
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Rotor syndrome

  • M Jirsa, AS Knisely, A Schinkel, S. Kmoch
  • Pagon RA, Adam MP, Bird TD, et al., eds…
  • 2012
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