Organic anion transporting polypeptide 1B3 (OATP1B3) is overexpressed in colorectal tumors and is a predictor of clinical outcome

@inproceedings{Lockhart2008OrganicAT,
  title={Organic anion transporting polypeptide 1B3 (OATP1B3) is overexpressed in colorectal tumors and is a predictor of clinical outcome},
  author={A Craig Lockhart and Elizabeth I Harris and Bonnie J Lafleur and Nipun B. Merchant and M. Kay Washington and Murray B. Resnick and Timothy J. Yeatman and Wooin Lee},
  booktitle={Clinical and experimental gastroenterology},
  year={2008}
}
BACKGROUND AND AIMS OATP1B3 is an organic anion transporting polypeptide (OATP) that functions as a multispecific transporter in the normal liver. We examined the expression and clinical significance of OATP1B3 in colon cancers in tissue microarrays. METHODS Immunohistochemistry was used to assess OATP1B3 protein expression in paraffinized colon tumor tissue microarrays. OATP1B3 immunostaining was evaluated by location and intensity. Relationships between OATP1B3 expression, known prognostic… CONTINUE READING

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Overexpression of organic anion transporting polypeptide 1B3 (OATP1B3) may be an early event in colon tumorigenesis, associated with apoptosis resistance in colon cancer [abstract

  • W Lee, A Belkhiri, AC Lockhart
  • Proc AACR
  • 2007
1 Excerpt

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