Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors.

@article{Oostendorp2009OrganicAP,
  title={Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors.},
  author={Roos L. Oostendorp and Evita van de Steeg and Cornelia M M van der Kruijssen and Jos H. Beijnen and Kathryn E. Kenworthy and Alfred H Schinkel and Jan H. M. Schellens},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2009},
  volume={37 4},
  pages={917-23}
}
Organic anion-transporting polypeptides (OATPs) are important uptake transporters that can have a profound impact on the systemic pharmacokinetics, tissue distribution, and elimination of several drugs. Previous in vivo studies of the pharmacokinetics of the lipophilic camptothecin (CPT) analog gimatecan suggested that the ATP-binding cassette (ABC) B1 (P-glycoprotein) and/or ABCG2 (breast cancer resistance protein) inhibitors elacridar and pantoprazole could inhibit transporters other than… CONTINUE READING

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