Organic alternatives to quantum dots for intraoperative near-infrared fluorescent sentinel lymph node mapping.

@article{Ohnishi2005OrganicAT,
  title={Organic alternatives to quantum dots for intraoperative near-infrared fluorescent sentinel lymph node mapping.},
  author={Shunsuke Ohnishi and Stephen J. Lomnes and Rita G. Laurence and Andrew Gogbashian and Giuliano Mariani and John V. Frangioni},
  journal={Molecular imaging},
  year={2005},
  volume={4 3},
  pages={172-81}
}
Intraoperative near-infrared (NIR) fluorescence imaging provides the surgeon with real-time image guidance during cancer and other surgeries. We have previously reported the use of NIR fluorescent quantum dots (QDs) for sentinel lymph node (SLN) mapping. However, because of concerns over potential toxicity, organic alternatives to QDs will be required for initial clinical studies. We describe a family of 800 nm organic heptamethine indocyanine-based contrast agents for SLN mapping spanning a… CONTINUE READING

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