Organic acids influence iron uptake in the human epithelial cell line Caco-2.

@article{Salovaara2002OrganicAI,
  title={Organic acids influence iron uptake in the human epithelial cell line Caco-2.},
  author={Susan Salovaara and Aksel Botne Sandberg and Thomas Andlid},
  journal={Journal of agricultural and food chemistry},
  year={2002},
  volume={50 21},
  pages={
          6233-8
        }
}
It has previously been suggested that organic acids enhance iron absorption. We have studied the effect of nine organic acids on the absorption of Fe(II) and Fe(III) in the human epithelial cell line Caco-2. The effect obtained was dose-dependent, and the greatest increase (43-fold) was observed for tartaric acid (4 mmol/L) on Fe(III) (10 micromol/L). Tartaric, malic, succinic, and fumaric acids enhanced Fe(II) and Fe(III) uptake. Citric and oxalic acid, on the other hand, inhibited Fe(II… CONTINUE READING
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