Organic acids and the uremic syndrome: protein metabolite hypothesis in the progression of chronic renal failure.

@article{Niwa1996OrganicAA,
  title={Organic acids and the uremic syndrome: protein metabolite hypothesis in the progression of chronic renal failure.},
  author={Toshimitsu Niwa},
  journal={Seminars in nephrology},
  year={1996},
  volume={16 3},
  pages={
          167-82
        }
}
A number of organic acids including phenols are accumulated in plasma of uremic patients because of reduced renal clearance. Some of them account for uremic problems such as reduced drug binding. Protein-bound organic acids such as hippuric acid, indoxyl sulfate, and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF), are markedly accumulated in uremic plasma, and produce defective protein binding of drugs. CMPF is tightly bound to serum albumin, and thus cannot be removed by conventional… CONTINUE READING

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