Organic Cation Transporter-Mediated Renal Secretion of Ipratropium and Tiotropium in Rats and Humans

@article{Nakanishi2011OrganicCT,
  title={Organic Cation Transporter-Mediated Renal Secretion of Ipratropium and Tiotropium in Rats and Humans},
  author={Takeo Nakanishi and Tsunemitsu Haruta and Yoshiyuki Shirasaka and Ikumi Tamai},
  journal={Drug Metabolism and Disposition},
  year={2011},
  volume={39},
  pages={117 - 122}
}
Ipratropium bromide (ipratropium) and tiotropium bromide (tiotropium), anticholinergic agents with bronchodilating properties, are used to treat patients with chronic obstructive pulmonary disease. Because they are actively secreted into urine, the interaction of these agents with organic cation transporters (OCTs/Octs) was examined in rat kidney slices and in cultured cells expressing rat Oct (rOct) or human OCT (hOCT). Uptake of radiolabeled ipratropium in rat kidney slices was significantly… Expand
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Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21).
  • I. Tamai
  • Biology, Medicine
  • Biopharmaceutics & drug disposition
  • 2013
TLDR
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