Organic Cation Transporter-Mediated Ergothioneine Uptake in Mouse Neural Progenitor Cells Suppresses Proliferation and Promotes Differentiation into Neurons

Abstract

The aim of the present study is to clarify the functional expression and physiological role in neural progenitor cells (NPCs) of carnitine/organic cation transporter OCTN1/SLC22A4, which accepts the naturally occurring food-derived antioxidant ergothioneine (ERGO) as a substrate in vivo. Real-time PCR analysis revealed that mRNA expression of OCTN1 was much… (More)
DOI: 10.1371/journal.pone.0089434

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Cite this paper

@inproceedings{Ishimoto2014OrganicCT, title={Organic Cation Transporter-Mediated Ergothioneine Uptake in Mouse Neural Progenitor Cells Suppresses Proliferation and Promotes Differentiation into Neurons}, author={Takahiro Ishimoto and Noritaka Nakamichi and Hiroshi Hosotani and Yusuke Masuo and Tomoko Sugiura and Yukio Kato}, booktitle={PloS one}, year={2014} }