Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome.

@article{Casey2007OrganellePI,
  title={Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome.},
  author={Tammy Casey and Josephine L. Meade and Eric W Hewitt},
  journal={Molecular & cellular proteomics : MCP},
  year={2007},
  volume={6 5},
  pages={767-80}
}
Natural killer (NK) cells and cytotoxic T lymphocytes eliminate virally infected and transformed cells. Target cell killing is mediated by the regulated exocytosis of secretory lysosomes, which deliver perforin and proapoptotic granzymes to the infected or transformed cell. Yet despite the central role that secretory lysosome exocytosis plays in the immune response to viruses and tumors, little is known about the molecular machinery that regulates the docking and fusion of this organelle with… CONTINUE READING