Organ weights and blood flows of sheep and pig for physiological pharmacokinetic modelling.

@article{Upton2008OrganWA,
  title={Organ weights and blood flows of sheep and pig for physiological pharmacokinetic modelling.},
  author={Richard N Upton},
  journal={Journal of pharmacological and toxicological methods},
  year={2008},
  volume={58 3},
  pages={198-205}
}
INTRODUCTION Physiological approaches to pharmacokinetic analysis require data on organ sizes and organ blood flows for a given species. An internally consistent compilation of these data for sheep and pigs is needed. Furthermore, it is desirable to be able to appropriately scale these data for individuals of different sizes to simulate hypothetical populations of sheep or pigs for pharmacokinetic/pharmacodynamic modelling. METHOD The literature was reviewed and tables of organ size (as a… CONTINUE READING
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