Organ-targeted high-throughput in vivo biologics screen identifies materials for RNA delivery.

@article{Chang2014OrgantargetedHI,
  title={Organ-targeted high-throughput in vivo biologics screen identifies materials for RNA delivery.},
  author={Tsung-Yao Chang and Peng Shi and Joseph D. Steinmeyer and Itthi Chatnuntawech and Paul W. Tillberg and Kevin T. Love and Peter M Eimon and Daniel G Anderson and Mehmet Fatih Yanik},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2014},
  volume={6 10},
  pages={926-34}
}
Therapies based on biologics involving delivery of proteins, DNA, and RNA are currently among the most promising approaches. However, although large combinatorial libraries of biologics and delivery vehicles can be readily synthesized, there are currently no means to rapidly characterize them in vivo using animal models. Here, we demonstrate high-throughput in vivo screening of biologics and delivery vehicles by automated delivery into target tissues of small vertebrates with developed organs… CONTINUE READING
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