Organ specificity of the dopamine1 receptor/adenylyl cyclase coupling defect in spontaneously hypertensive rats.

@article{Felder1993OrganSO,
  title={Organ specificity of the dopamine1 receptor/adenylyl cyclase coupling defect in spontaneously hypertensive rats.},
  author={R A Felder and Shizuo Kinoshita and K Ohbu and M. Maral Mouradian and David R. Sibley and Frederick J. Monsma and Takashi Minowa and Mari T. Minowa and L M Canessa and Pedro A. Jos{\'e}},
  journal={The American journal of physiology},
  year={1993},
  volume={264 4 Pt 2},
  pages={R726-32}
}
The coupling between the dopamine1 (DA1) receptor and the G protein/adenylyl cyclase (AC) enzyme complex is defective in the proximal convoluted tubule (PCT) of 20-wk-old spontaneously hypertensive rats (SHRs). Because this coupling defect could have been due to desensitization secondary to elevated renal dopamine levels in the adult animal, we studied the interaction between DA1 receptors and AC in PCT of rats as early as 3 wk of age, a time when renal dopamine levels are similar in SHRs and… CONTINUE READING

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