Organ-specificity and diagnostic value of cell-mediated immunity against a liver-specific membrane protein: Studies in hepatic and non-hepatic diseases

  title={Organ-specificity and diagnostic value of cell-mediated immunity against a liver-specific membrane protein: Studies in hepatic and non-hepatic diseases},
  author={Karl‐Hermann Meyer zum B{\"u}schenfelde and Alfredo Alberti and Wilfred Niels Arnold and J. Freudenberg},
  journal={Klinische Wochenschrift},
ZusammenfassungBei Patienten mit chronisch-aktiver Hepatitis (CAH) (n=58) konnte bei 70% der HBsAg-negativen und 48% der HBsAg-positiven Fälle eine zelluläre Immunreaktion (CMI) gegenüber humanen leberspezifischen Proteinen (HLPI) aus Plasmamembranen nachgewiesen werden.Mit HBsAg als Antigen war nur bei 12% der HBsAg-negativen und 24% der HBsAg-positiven CAH eine CMI vorhanden. Unter Berücksichtigung von HBsAg und Autoantikörpern im Serum von Patienten mit CAH konnte eine Einteilung in 4… Expand
The diagnostic significance of intrahepatocellular hepatitis-B-surface-antigen (HBsAg), hepatitis-B-core-antigen (HBcAg) and IgG for the classification of inflammatory liver diseases
Cases one year after complete recovery of acute virus B-hepatitis had no HB-components in their liver tissue, and 2 cases without immunoelimination of HBsAg developed chronic active hepatitis within one year. Expand
Anti-HBc, HBeAg and DNApolymerase activity in healthy HBsAg carriers and patients with inflammatory liver diseases
On anti-HBc-titers, HBeAg, DNApolymerase activity in the serum and intracellular HBsAg in healthy HBs Ag-carriers and patients withHBsAg-positive inflammatory liver diseases is reported. Expand
Estimation of IgG-antiglobulins in sera of patients with rheumatoid arthritis and chronic liver disorders
Antiglobulin factors of the IgG class were measured in human sera by a modified immunoadsorbent-technique involving absorption to and elution from insoluble preparations of horse IgG. Expand
Histokompatibilitäts-(HLA) Antigene bei Patienten mit HBsAg-positiver und -negativer chronisch aktiver Hepatitis und gesunden Trägern von HBsAg und Anti-HBs
No indications could be found for HLA-associated factors in the different behaviour to the hepatitis-B virus as well as no significant differences in the frequencies of the HLA antigens tested in patients with CAH and healthy carriers of HBsAg and Anti-HBs. Expand
The role of liver membrane antigens as targets in autoimmune type liver disease
In the present paper a review is given of the published data concerning the identification of liver membrane antigens and the present knowledge of immune reactions against these target antigen will be reported and their clinical significance will be discussed. Expand
Detection of HBsAg containing cells in liver biopsies by different stains and classification of positively reacting ground-glass hepatocytes
The diagnostic significance of orcein, aldehydthionine, and chromotrope anilinblue stains for the demonstration of HBsAg containing hepatocytes was investigated in 602 unselected liver biopsies and the orceIn stain yielded the best results. Expand
Antigenic relationship between Chang liver cells and human hepatocytes
Chang liver cells can be used as in vitro system to study immune reactions against LSP in human inflammatory liver diseases and it could be demonstrated that Chang liver cells bear LSP on their membranes. Expand
The immunopathology of acute type B hepatitis
  • L. Bianchi
  • Medicine
  • Springer Seminars in Immunopathology
  • 2005
Although the identification of the hepatitis B virus (HBV) and the availability of immunologic markers of infection have greatly enhanced our knowlodge about hepatitis B, the natural history of theExpand
Theimunopathogenesis of cronic HBV inducedliver disease
Significant effort must now be focused on the basic biology of virus infection, replication, and effects on hepatocellular metabolism before it will be possible to perform the definitive experiments to elucidate the role played by the immune system in the pathogenesis of this disease. Expand


Celluläre Immunreaktionen gegenüber dem Hepatitis-assoziierten Antigen (HAA) und homologem leberspezifischem Antigen (HLP) bei akuten HAA-positiven Hepatitiden
Die cellularen Immunreaktionen gegenuber homologen leberspezifischen Proteinen (HLP) und dem Hepatitis-assoziierten Antigen (HAA) wurden bei Patienten mit akuter HAA-positiver Hepatitis unterExpand
Immunelektrophoretischer Nachweis von „Hepatitis-Associated-Antigen“ (Au/SH-Antigen)
For detection of Au/SH-Antigen and antibody an immunoelectrophoretic method was developed according to the principle of crossing over electrophoresis and accurate results may be obtained after 2 1/2 and 3 1-2 hrs. Expand
Celluläre Immunreaktionen gegenüber homologen leberspezifischen Antigenen (HLP) bei chronischen Leberentzündungen
The results support the view of the importance of cell- mediated immune reactions towards liver antigens in the pathogenesis of chronic active hepatitis. Expand
HL-A bei Lebererkrankungen
Patients treated or controlled at the Second Medical University Clinic and Outpatientclinic Mainz for acute hepatitis, chronic persistent hepatitis, autoimmune chronic aggressive hepatitis, or liver diseases due to metabolic disorders as well as normal controls were typed for HL-A by the NIH standard test. Expand
The role of circulating hepatitis B antigen/antibody immune complexes in the pathogenesis of vascular and hepatic manifestations in polyarteritis nodosa
Seroconversion or the presence of hepatitis B antibody alone was associated with improved prognosis and Circulating hepatitis B antigen antibody complexes may be responsible for vasculitis or polyarteritis but do not appear to be pathogenic for the liver. Expand
Celluläre Immunreaktionen gegenüber dem Hepatitisassoziierten Antigen (HAA) und homologem leberspezifischen Protein (HLP) bei akuten HAA-positiven Hepatitiden
SummaryThe cell-mediated immune responses towards homologous, liver-specific antigens (HLP) and hepatitis-associated antigen (HAA) were studied in patients with acute HAA-positive hepatitis using theExpand
Cell-mediated immune response to hepatitis B antigen in patients with liver disease
The data suggest that many patients with AVH in whom HBAg is undetectable may have hepatitis B and that measurement ofin vitro MIF to HBAG is a sensitive index for establishing the etiological role of the antigen in the liver disease. Expand
Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis.
An organ-specific lipoprotein has been isolated from normal human liver and cell-mediated immune responses to it have been assayed in patients with chronic liver diseases using the leucocyte-migration test, with significant inhibition of migration restricted to patients with postulated autoimmune diseases of the liver. Expand
Association of autoimmune active chronic hepatitis with HL-A1,8.
A hypothetical influence of genes expressing HL-A1,8 on the proliferative or tolerance response of immunocytes could account for the linkage disequilibrium between these antigens, and also help in the interpretation of the inherited component in autoimmune disease. Expand
Cell-mediated Immune Response in Primary Biliary Cirrhosis to a Protein Fraction from Human Bile
Results suggest that the initial bile duct lesion in primary biliary cirrhosis may be associated with a cell-mediated response to antigens—perhaps derived from biliary duct epithelial cells—which may be normal constituents of hepatic bile. Expand