Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene.

@article{Shi2010OrganspecificRO,
  title={Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene.},
  author={Zhanquan Shi and Nadine Dragin and Marina G{\'a}lvez-Peralta and Lucia F. Jorge-Nebert and Marian L Miller and Bin Wang and Daniel W. Nebert},
  journal={Molecular pharmacology},
  year={2010},
  volume={78 1},
  pages={
          46-57
        }
}
  • Zhanquan Shi, Nadine Dragin, +4 authors Daniel W. Nebert
  • Published in Molecular pharmacology 2010
  • Biology, Medicine
  • Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental toxicants derived from sources that include cigarette smoke, petroleum distillation, gas- and diesel-engine exhaust, and charcoal-grilled food. The gastrointestinal tract is the principal route of PAH exposures, even when inhaled. The most thoroughly studied prototype of PAHs is benzo[a]pyrene (BaP), well known to be toxic, mutagenic, and carcinogenic in various tissues and cell types. This lab has previously shown… CONTINUE READING

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