Organ-specific pattern of inhibition of diltiazem metabolism at steady state in rabbits.

@article{Lefebvre1996OrganspecificPO,
  title={Organ-specific pattern of inhibition of diltiazem metabolism at steady state in rabbits.},
  author={Mario Lefebvre and Gilles Caill{\'e} and Patrick du Souich},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={279 2},
  pages={902-7}
}
Plasma levels of diltiazem, after its chronic administration, are usually higher than predicted. Because several organs contribute to diltiazem metabolism, this study aimed to determine the effect of an infusion of diltiazem to steady state on the ability of the intestine, liver and lungs to metabolize diltiazem and its metabolites N-desmethyldiltiazem (MA… CONTINUE READING