Organ-specific innate immune responses in a mouse model of invasive candidiasis.

@article{Lionakis2011OrganspecificII,
  title={Organ-specific innate immune responses in a mouse model of invasive candidiasis.},
  author={Michail S. Lionakis and Jean K Lim and Chyi-chia Lee and Philip G. M. Murphy},
  journal={Journal of innate immunity},
  year={2011},
  volume={3 2},
  pages={180-99}
}
In a fatal mouse model of invasive candidiasis (IC), fungal burden changes with variable dynamics in the kidney, brain, spleen, and liver and declines in all organs except for the kidney, which inexorably loses function. Since leukocytes are required to control Candida, we hypothesized that differential leukocyte infiltration determines organ-specific outcome of the infection. We defined leukocyte accumulation in the blood, kidney, brain, spleen, and liver after infection using fluorescent… CONTINUE READING

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