Organ siderosis and hemophagocytosis during acute graft-versus-host disease.

  title={Organ siderosis and hemophagocytosis during acute graft-versus-host disease.},
  author={A. Nogai and Yu Shi and Daniel P{\'e}rez-Hern{\'a}ndez and Steffen Cordes and J{\"o}rg Mengwasser and Sarah Mertlitz and Katarina Riesner and Martina Kalupa and Jan-Hendrik Erdmann and Reinhard Ziebig and Gunnar Dittmar and Sunita Nathan},
  volume={101 8},
Iron overload prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) due to blood transfusions is associated with increased non-relapse mortality (NRM) and with low overall survival.1,2 After allo-HSCT, high iron content in liver biopsies and elevated ferritin concentrations in blood, used as a surrogate parameter for iron overload, are also related to NRM.3–6 The cellular and molecular mechanisms behind this association, however, are yet to be clarified. In particular… CONTINUE READING
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